abstract：:The genus Ononis has important value as traditional drugs and foods. In the present work, we aimed to assess the chemical profiles and biological effects of Ononis natrix subsp. hispanica extracts (ethyl acetate, methanol, and water). For chemical profile, total and individual phenolic components were detected. For bi...

journal_title：Frontiers in pharmacology

authors： Yerlikaya S,Zengin G,Mollica A,Baloglu MC,Celik Altunoglu Y,Aktumsek A

更新日期：2017-09-01 00:00:00

abstract：:The number of colorectal cancer (CRC) cases have increased gradually year by year. In fact, CRC is one of the most widely diagnosed cancer in men and women today. This disease is usually diagnosed at a later stage of the development, and by then, the chance of survival has declined significantly. Even though substanti...

journal_title：Frontiers in pharmacology

authors： Hon KW,Abu N,Ab Mutalib NS,Jamal R

更新日期：2017-08-28 00:00:00

abstract：:Aging is associated with age-related diseases and an increase susceptibility of cancer. Dissecting the molecular mechanisms that underlie aging and longevity would contribute to implications for preventing and treating the age-dependent diseases or cancers. Multiple signaling pathways such as the insulin/IGF-1 signali...

journal_title：Frontiers in pharmacology

authors： Sun X,Chen WD,Wang YD

更新日期：2017-08-23 00:00:00

abstract：:Recently, the use of plant-derived medicines is increasing interest in the prevention and treatment of a variety of disorders including metabolic syndromes. Metabolic syndrome is one of the major risk factors for cardiovascular diseases (CVDs) and incidence of mortality worldwide. Scientific evidence suggests that And...

journal_title：Frontiers in pharmacology

authors： Islam MT

更新日期：2017-08-23 00:00:00

abstract：:Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase recently implicated in biochemical, physiological, and behavioral responses to ethanol. Thus, manipulation of ALK signaling may represent a novel approach to treating alcohol use disorder (AUD). Ethanol induces adaptations in glutamatergic synapses onto nu...

journal_title：Frontiers in pharmacology

authors： Mangieri RA,Maier EY,Buske TR,Lasek AW,Morrisett RA

更新日期：2017-08-15 00:00:00

abstract：:Phytochemical studies are seeking new alternatives to prevent or treat cancer, including different types of leukemias. Campomanesia adamantium, commonly known as guavira or guabiroba, exhibits pharmacological properties including antioxidant, antimicrobial, and antiproliferative activities. Considering the anticancer ...

journal_title：Frontiers in pharmacology

authors： Campos JF,Espindola PPT,Torquato HFV,Vital WD,Justo GZ,Silva DB,Carollo CA,de Picoli Souza K,Paredes-Gamero EJ,Dos Santos EL

更新日期：2017-08-14 00:00:00

abstract：:Imatinib (IM), as first inhibitor of the oncogenic tyrosine kinase BCR-ABL, has been widely used to treat chronic myeloid leukemia (CML) for decades in clinic. However, resistance to IM usually occurs in CML patients. The bone marrow (BM), as the predominant microenvironment of CML, secretes an abundant amount of cyto...

journal_title：Frontiers in pharmacology

authors： Zhang X,Liu Y,Lu L,Huang S,Ding Y,Zhang Y,Guo Q,Li Z,Zhao L

更新日期：2017-08-11 00:00:00

abstract：:Ginsenoside is a major active component of ginseng, which exhibits various pharmacological properties such as hepatoprotection, tumor suppression and diabetes resistance. In this study, the anti-diabetic effects of protopanaxadiol (PPD) and protopanaxatriol (PPT)-type saponins were explored and compared in high-fat di...

journal_title：Frontiers in pharmacology

authors： Deng J,Liu Y,Duan Z,Zhu C,Hui J,Mi Y,Ma P,Ma X,Fan D,Yang H

更新日期：2017-08-02 00:00:00

abstract：:Statin therapy may induce skeletal muscle damage ranging from myalgia to severe rhabdomyolysis. Our previous preclinical studies showed that statin treatment in rats involves the reduction of skeletal muscle ClC-1 chloride channel expression and related chloride conductance (gCl). An increase of the activity of protei...

journal_title：Frontiers in pharmacology

authors： Camerino GM,Musumeci O,Conte E,Musaraj K,Fonzino A,Barca E,Marino M,Rodolico C,Tricarico D,Camerino C,Carratù MR,Desaphy JF,De Luca A,Toscano A,Pierno S

更新日期：2017-07-27 00:00:00

abstract：:Field independence (FI) has been found to correlate with a wide range of cognitive processes requiring cognitive restructuring. Cognitive restructuring, that is going beyond the information given by the setting, is pivotal in creating stable mental representations of the environment, the so-called "cognitive maps," an...

journal_title：Frontiers in pharmacology

authors： Boccia M,Vecchione F,Piccardi L,Guariglia C

更新日期：2017-07-25 00:00:00

abstract：:In metastatic renal cell carcinoma, complete response to first-line antiangiogenic agents is rare and resistance to therapy often develops. Protocols for sequential treatment with angiogenesis and mTOR inhibitors are under evaluation to improve outcomes. In this observational, real-world study, patients received a fir...

journal_title：Frontiers in pharmacology

authors： Rossetti S,D'Aniello C,Iovane G,Scagliarini S,Laterza MM,De Vita F,Savastano C,Cartenì G,Porricelli MA,Berretta M,Pisconti S,Facchini G,Cavaliere C

更新日期：2017-07-20 00:00:00

abstract：:Background and Objectives: Although the relationship between the use of proton pump inhibitors (PPIs) and pulmonary tuberculosis (TB) in Taiwan published in 2014. Due to just only one article and not enough comprehensively, we explore this issue. Methods: We conducted a population-based case-control study to identify ...

journal_title：Frontiers in pharmacology

authors： Cheng KC,Liao KF,Lin CL,Lai SW

更新日期：2017-07-19 00:00:00

abstract：:The potential of multifunctional wound heal biomaterial relies on the optimal content of therapeutic constituents as well as the desirable physical, chemical, and biological properties to accelerate the healing process. Formulating biomaterials such as amnion or collagen based scaffolds with natural products offer an ...

journal_title：Frontiers in pharmacology

authors： Sivasubramanian S,Chandrasekar G,Svensson Akusjärvi S,Thangam R,Sathuvan M,Kumar RBS,Hussein H,Vincent S,Madhan B,Gunasekaran P,Kitambi SS

更新日期：2017-07-18 00:00:00

abstract：:Positive links have been found between periodontitis and numerous diseases in humans via persistent inflammation throughout the body. However, the main factors responsible for maintaining this pro-inflammatory condition are poorly understood. The spleen, the largest secondary immune organ, is a central hub regulating ...

journal_title：Frontiers in pharmacology

authors： Dekita M,Wu Z,Ni J,Zhang X,Liu Y,Yan X,Nakanishi H,Takahashi I

更新日期：2017-07-17 00:00:00

abstract：:Although initially described as an anti-tumor mediator, tumor necrosis factor-alpha (TNF) is generally considered as the master pro-inflammatory cytokine. It plays a crucial role in the pathogenesis of inflammatory diseases, such as rheumatoid arthritis (RA), inflammatory bowel disease, ankylosing spondylitis (AS), an...

journal_title：Frontiers in pharmacology

authors： Li P,Zheng Y,Chen X

更新日期：2017-07-12 00:00:00

abstract：:The cardiac ischemia-reperfusion (I/R) injury greatly influences the therapeutic effect and remains an urgent challenge in clinical therapy. Polypharmacology opens a new therapeutic opportunity to design drugs with a specific target for improving the efficacy. In this study, we first forecasted that Rosmarinic acid (R...

journal_title：Frontiers in pharmacology

authors： Han J,Wang D,Ye L,Li P,Hao W,Chen X,Ma J,Wang B,Shang J,Li D,Zheng Q

更新日期：2017-07-11 00:00:00

abstract：:Cholesterol is essential for development, growth, and maintenance of organisms. Mutations in cholesterol biosynthetic genes are embryonic lethal and few polymorphisms have been so far associated with pathologies in humans. Previous analyses show that lanosterol 14α-demethylase (CYP51A1) from the late part of cholester...

journal_title：Frontiers in pharmacology

authors： Režen T,Ogris I,Sever M,Merzel F,Golic Grdadolnik S,Rozman D

更新日期：2017-06-30 00:00:00

abstract：:Black peppercorns (Piper nigrum L.) elicit a pungent and tingling oral impression. Their pungency is partially explained by the agonist activity of some of their active principles, especially piperine, on TRP channels. However, we recently showed that piperine, as well as other pungent compounds, also possess a marked...

journal_title：Frontiers in pharmacology

authors： Beltrán LR,Dawid C,Beltrán M,Levermann J,Titt S,Thomas S,Pürschel V,Satalik M,Gisselmann G,Hofmann T,Hatt H

更新日期：2017-06-26 00:00:00

abstract：:Neuropathic pain caused by nerve damage is a common and severe class of chronic pain. Disease-modifying clinical therapies are needed as current treatments typically provide only symptomatic relief; show varying clinical efficacy; and most have significant adverse effects. One approach is targeting either neurotrophic...

journal_title：Frontiers in pharmacology

authors： Sidorova YA,Bespalov MM,Wong AW,Kambur O,Jokinen V,Lilius TO,Suleymanova I,Karelson G,Rauhala PV,Karelson M,Osborne PB,Keast JR,Kalso EA,Saarma M

更新日期：2017-06-21 00:00:00

abstract：:γ-aminobutyric acid (GABA) or glucagon-like peptide-1 based drugs, such as sitagliptin (a dipeptidyl peptidase-4 inhibitor), were shown to induce beta cell regenerative effects in various diabetic mouse models. We propose that their combined administration can bring forth an additive therapeutic effect. We tested this...

journal_title：Frontiers in pharmacology

authors： Liu W,Son DO,Lau HK,Zhou Y,Prud'homme GJ,Jin T,Wang Q

更新日期：2017-06-20 00:00:00

abstract：:Background: Little is known about the humanistic burden of small cell lung cancer (SCLC), specifically the impact on health-related quality of life (HRQoL). The aim of this systematic literature review was to explore the impact of SCLC on HRQoL and the patient reported outcomes (PROs) used to capture this impact. Meth...

journal_title：Frontiers in pharmacology

authors： Bennett BM,Wells JR,Panter C,Yuan Y,Penrod JR

更新日期：2017-06-15 00:00:00

abstract：:Objectives: The aim of this study was to review the requirements for the reimbursement of biosimilars and to compare the reimbursement status, market share, and reimbursement costs of biosimilars in selected Central and Eastern European (CEE) countries. Methods: A questionnaire-based survey was conducted between Novem...

journal_title：Frontiers in pharmacology

authors： Kawalec P,Stawowczyk E,Tesar T,Skoupa J,Turcu-Stiolica A,Dimitrova M,Petrova GI,Rugaja Z,Männik A,Harsanyi A,Draganic P

更新日期：2017-06-08 00:00:00

abstract：:Tacrolimus (Tac) is a profoundly effective immunosuppressant that reduces the risk of rejection after solid organ transplantation. However, its use is hampered by its narrow therapeutic window along with its highly variable pharmacological (pharmacokinetic [PK] and pharmacodynamic [PD]) profile. Part of this variabili...

journal_title：Frontiers in pharmacology

authors： Woillard JB,Mourad M,Neely M,Capron A,van Schaik RH,van Gelder T,Lloberas N,Hesselink DA,Marquet P,Haufroid V,Elens L

更新日期：2017-06-08 00:00:00

abstract：:Crataegus oxyacantha is an important herbal supplement and famous for its antioxidant potential. The antioxidant in combination with anticholinesterase activity can be considered as an important target in the management of Alzheimer's disease. The compounds isolated from C. oxyacantha were evaluated for cholinesterase...

journal_title：Frontiers in pharmacology

authors： Ali M,Muhammad S,Shah MR,Khan A,Rashid U,Farooq U,Ullah F,Sadiq A,Ayaz M,Ali M,Ahmad M,Latif A

更新日期：2017-06-07 00:00:00

abstract：:Objective: Advanced age is associated with impaired angiogenesis in part because of mitochondrial dysfunction. We have recently reported that leonurine exerts protective effects in neuron via regulation of mitochondrial function. The aim of this study was to explore whether leonurine is able to attenuate mitochondrial...

journal_title：Frontiers in pharmacology

authors： Qi J,Wang JJ,Duan JL,Lu ZY,Yuan YG

更新日期：2017-06-06 00:00:00

abstract：:Fibrosis is a major player in cardiovascular disease, both as a contributor to the development of disease, as well as a post-injury response that drives progression. Despite the identification of many mechanisms responsible for cardiovascular fibrosis, to date no treatments have emerged that have effectively reduced t...

journal_title：Frontiers in pharmacology

authors： McVicker BL,Bennett RG

更新日期：2017-05-31 00:00:00

abstract：:Targeting metabolic enzymes is believed to provide new therapeutic opportunities for cancer therapy. Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that importantly coordinates glycolysis, pentose phosphate pathway (PPP) flux and serine biosynthesis in cancer cells and hence gains increasing interest of inhi...

journal_title：Frontiers in pharmacology

authors： Li X,Tang S,Wang QQ,Leung EL,Jin H,Huang Y,Liu J,Geng M,Huang M,Yuan S,Yao XJ,Ding J

更新日期：2017-05-30 00:00:00

abstract：:Pickering emulsion, a kind of emulsion stabilized only by solid particles locating at oil-water interface, has been discovered a century ago, while being extensively studied in recent decades. Substituting solid particles for traditional surfactants, Pickering emulsions are more stable against coalescence and can obta...

journal_title：Frontiers in pharmacology

authors： Yang Y,Fang Z,Chen X,Zhang W,Xie Y,Chen Y,Liu Z,Yuan W

更新日期：2017-05-23 00:00:00

abstract：:Background and purpose: We have shown that in vitro treatment with cannabidiol (CBD, 2 h) enhances endothelial function in arteries from Zucker diabetic fatty (ZDF) rats, partly due to a cyclooxygenase (COX)-mediated mechanism. The aim of the present study was to determine whether treatment with CBD in vivo would also...

journal_title：Frontiers in pharmacology

authors： Wheal AJ,Jadoon K,Randall MD,O'Sullivan SE

更新日期：2017-05-18 00:00:00

abstract：:The dialysis of human and mouse neutrophils in patch clamp experiments in the conventional whole-cell mode induces the emergence of a chloride (Cl-) current that appeared to be primarily regulated by cytoplasmic ionic strength. The characteristics of this current resembled that of the classical, and ubiquitous volume-...

journal_title：Frontiers in pharmacology

authors： Behe P,Foote JR,Levine AP,Platt CD,Chou J,Benavides F,Geha RS,Segal AW

更新日期：2017-05-12 00:00:00

abstract：:In the last years, many clinical studies have revealed that some cisplatin-treated cancer survivors have a significantly increased risk of cardiovascular events, being cisplatin-induced cardiovascular toxicity an increasing concern. The aim of the present work was to evaluate the cardiovascular alterations induced by ...

journal_title：Frontiers in pharmacology

authors： Herradón E,González C,Uranga JA,Abalo R,Martín MI,López-Miranda V

更新日期：2017-05-08 00:00:00

abstract：:Purpose: Asian populations have around 40-60% frequency of reduced function allele CYP2D6∗10 compared to 1-2% in Caucasian populations. The wide range of CYP2D6 enzyme activities in subjects with the CYP2D6∗10 variant is a big concern for clinical practice. The quantitative analysis measuring the impact of CYP2D6 enzy...

journal_title：Frontiers in pharmacology

authors： Chen R,Zheng X,Hu P

更新日期：2017-05-02 00:00:00

abstract：:Background and Aims:Kickxia ramosissima (Wall.) Janch (or Nanorrhinum ramosissimum (Wall.) Betsche is a well-known medicinal plant in Pakistan that is traditionally used in diabetic and inflammatory conditions. Because little information is available on its phytochemical composition, a range of constituents were isola...

journal_title：Frontiers in pharmacology

authors： Amin A,Tuenter E,Foubert K,Iqbal J,Cos P,Maes L,Exarchou V,Apers S,Pieters L

更新日期：2017-05-01 00:00:00

abstract：:Background: Clozapine, an antipsychotic used in treatment-resistant schizophrenia, has adverse gastrointestinal effects with significant associated morbidity and mortality. However, its effects on defined patterns of colonic contractile activity have not been assessed. Method: We used novel radial and longitudinal spa...

journal_title：Frontiers in pharmacology

authors： Every-Palmer S,Lentle RG,Reynolds G,Hulls C,Chambers P,Dunn H,Ellis PM

更新日期：2017-04-24 00:00:00

abstract：:Objective: A generic vaginal progesterone gel has recently been developed in China. Little is known about its pharmacokinetic properties in Chinese subjects. The purpose of our study was to investigate the pharmacokinetics of three forms of vaginal progesterone gel (test formulations at 4 and 8% strength vs. a referen...

journal_title：Frontiers in pharmacology

authors： Wu G,Chen J,Hu X,Zhou H,Liu J,Lv D,Wu L,Shentu J

更新日期：2017-04-20 00:00:00

abstract：:Chemotherapy is a leading intervention against cancer. Albeit highly effective, chemotherapy has a multitude of deleterious side-effects including skeletal muscle wasting and fatigue, which considerably reduces patient quality of life and survivability. As such, a defense against chemotherapy-induced skeletal muscle d...

journal_title：Frontiers in pharmacology

authors： Sorensen JC,Petersen AC,Timpani CA,Campelj DG,Cook J,Trewin AJ,Stojanovska V,Stewart M,Hayes A,Rybalka E

更新日期：2017-04-10 00:00:00

abstract：:Objectives: The aim of this study is to conduct an analysis on the regulation and application of managed entry agreements (MEA) for oncology drugs across different European countries. Methods: Literature search and document analysis were performed between September 2015 and June 2016 to collect information on the regu...

journal_title：Frontiers in pharmacology

authors： Pauwels K,Huys I,Vogler S,Casteels M,Simoens S

更新日期：2017-04-04 00:00:00

abstract：:The development of compounds able to modify biological functions largely took advantage of parallel synthesis to generate a broad chemical variance of compounds to be tested for the desired effect(s). The budding yeast Saccharomyces cerevisiae is a model for pharmacological studies since a long time as it represents a...

journal_title：Frontiers in pharmacology

authors： Brilli M,Trabocchi A,Weil T,Cavalieri D,Stefanini I

更新日期：2017-03-30 00:00:00

abstract：:The use of magnetic iron oxide nanoparticles in biomedicine has evolved intensely in the recent years due to the multiple applications of these nanomaterials, mainly in domains like cancer. The aim of the present study was: (i) to develop biocompatible colloidal suspensions based on magnetic iron oxide nanoparticles a...

journal_title：Frontiers in pharmacology

authors： Coricovac DE,Moacă EA,Pinzaru I,Cîtu C,Soica C,Mihali CV,Păcurariu C,Tutelyan VA,Tsatsakis A,Dehelean CA

更新日期：2017-03-28 00:00:00

abstract：:Cytochrome P450 enzymes are often responsible for the toxic and carcinogenic effects of toxicants, such as aflatoxin B1 (AFB1). The human hepatic CYP2A6 enzyme mediates the oxidative metabolism of several procarcinogens. In this study, we characterized a partial sequence of CYP2A6 gene from Arbor Acres (AA) broiler an...

journal_title：Frontiers in pharmacology

authors： Muhammad I,Sun X,Wang H,Li W,Wang X,Cheng P,Li S,Zhang X,Hamid S

更新日期：2017-03-21 00:00:00